Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease
• How did AJs evolve?
• How do cadherins and catenins interact to assemble AJs and mediate adhesion?
• How do AJs interface with other cellular machinery to couple adhesion with the whole cell?
• How do AJs affect cell behaviour and multicellular development?
• How can abnormal AJ activity lead to disease?
1. An introduction to adherens junctions: from molecular mechanisms to tissue development and disease; Tony Harris
Part I: How AJs evolved
2. Evolution of the cadherin-catenin complex; Hiroki Oda
Part II: How cadherins and catenins interact to assemble AJs
3. The three-dimensional structure of the cadherin-catenin complex; Noboru Ishiyama and Mitsuhiko Ikura
4. Biophysics of cadherin adhesion; Deborah Leckband and Sanjeevi Sivasankar
5. Adherens junction assembly; Sergey Troyanovski
Part III: How AJs interface with other cellular machinery
6. The cytoskeleton and classical cadherin adhesions; Siew Ping Han and Alpha Yap
7. Immunoglobulin superfamily receptors and adherens junctions; Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori and Yoshimi Takai
8. Signaling from the adherens junction; Abbye McEwen, David Escobar and Cara Gottardi
9. Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling; Benjamin Nanes and Andrew Kowalczyk
Part IV: How AJs affect cell behaviour and multicellular development
10. Adherens junctions during cell migration; Sandrine Etienne-Manneville
11. Adherens junctions and cadherins in Drosophila development; Annalisa Letizia and Marta Llimargas
12. Adherens junctions in C. elegans embryonic morphogenesis; Stephen Armenti and Jeremy Nance
13. Cadherin function during Xenopus gastrulation; Rudolf Winklbauer
14. Adherens junctions in mammalian development, homeostasis and disease: lessons from mice; Barbara Boggetti and Carien Niessen
Part V: How AJs affect tissue homeostasis and disease
15. Adherens junctions and stem cells; Terry Lechler
16. Adherens junctions and cancer; Valeri Vasioukhin
17. Adherens junctions and pathogens entry; Georgios Nikitas and Pascale Cossart