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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium
Buch
Buch
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Fachbuch
2012

Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

Kollektion

Advances in Experimental Medicine and Biology

ISBN
EAN
978-94-007-4314-4
9789400743144
Artikel-Nr.
ELNL367
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Rabatt
-13.7
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CHF 291.00
CHF
251.12
Anzahl
1
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Lieferzeit
5
Arbeitstage
Freitag
30.07.2021
speech-bubble-svg Beschreibung
Coxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.
Inhaltsverzeichnis
1. History and prospects of Coxiella burnetii research; Karim E. Hechemy2. Phylogenetic diversity, virulence and comparative genomics; Erin J. van Schaik and James E. Samuel3. Defense mechanisms against oxidative stress in Coxiella burnetii: Adaptation to a unique intracellular niche; Katja Mertens and James E. Samuel4. Lipopolysaccharide of Coxiella burnetii; Craig T. Narasaki and Rudolf Toman5. Components of protective immunity; Guoquan Zhang, Yan Zhang and James Samuel6. Proteome of Coxiella burnetii; Robert Ihnatko, Edward Shaw and Rudolf Toman7. Coxiella subversion of intracellular host signaling; S. Kauser Hussain and Daniel E. Voth8. The Coxiella burnetii parasitophorous vacuole; Eric Ghigo, María I. Colombo and Robert A. Heinzen9. Coxiella burnetii secretion systems; Justin A. McDonough, Hayley J. Newton and Craig R. Roy10. Role of lipids in Coxiella burnetii infection; Stacey D. Gilk11. Axenic growth of Coxiella burnetii; Anders Omsland12. Developmental biology of Coxiella burnetii; Michael F. Minnick and Rahul Raghavan 13. Genetic manipulation of Coxiella burnetii; Paul A. Beare14. Role of innate and adaptive immunity in the control of Q fever; Christian Capo and Jean-Louis Mege15. Immune response and Coxiella burnetii invasion; Amira Ben Amara, Yassina Bechah and Jean-Louis Mege16. Antigenic analysis for vaccines and diagnostics; Laura R. Hendrix and Chen Chen17. Epidemic Q Fever in humans in the Netherlands; Wim van der Hoek, Gabriëlla Morroy, Nicole H.M. Renders, Peter C. Wever, Mirjam H.A. Hermans, Alexander C.A.P. Leenders, and Peter M. Schneeberger18. Coxiella-like endosymbionts; Jianmin Zhong19. Molecular typing of Coxiella burnetii (Q fever); Robert Massung, Sally Cutler and Dimitrios Frangoulidis
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Research
Publikation
Niederlande
22.06.2012
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Sprache
Englisch
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Hardcover
406 Seiten
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