Atlas of Thyroid and Neuroendocrine Tumor Markers
This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues.
This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments.
Circulating biomarkers: biological basis, methods and interpretation criteria.- Thyroid tumors: pathology and molecular patholog .- Differentiated thyroid cancer.- Diagnosis, therapy and follow-up.- Thyroglobulin and Thyroglobulin Autoantibodies.- Circulating molecular markers: an overview .- Medullary Thyroid Carcinoma.- Diagnosis, therapy and follow-up.- Calcitonin and Carcinoembryonic Antige .- Procalcitonin: are we ready for clinical use?.- Aggressive and Rare Thyroid Carcinoma:.Diagnosis and clinical management.- Circulating mucines and cytokeratins in aggressive thyroid cancers.- Neuroendocrine tumors: pathology and molecular pathology.- Neuroendocrine tumors: diagnosis, therapy and follow-up.- Chromogranin-A and other neuroendocrine tumour markers.- Neuroendocrine gene transcripts.
Luca Giovanella completed his doctoral degree at the Medical School of University of Pavia (I) in 1991. Subsequently, he obtained his post-graduate Degree in Nuclear Medicine (1995) and Endocrinology (2000) at the University of Milan, as well as an Executive Master in Health Organization and Human Resources Management (2000) at the Politecnico Universitario of Milan. He served as a consultant at the Department of Nuclear Medicine-University Hospital "Fondazione Macchi" of Varese from 1993 to 2002, and chaired the Thyroid Unit and the Laboratory for Endocrinology from 1995 to 2002. He serves as Chairman of the Clinic of Nuclear Medicine and Molecular Imaging and the Competence Centre for Thyroid Diseases at the Ente Ospedaliero Cantonale (EOC) in Bellinzona and Lugano (Switzerland) since 2003. He also serves as Scientific Advisor to the Department of Clinical Chemistry and Laboratory Medicine at EOC in Bellinzona. He served as Privat-Dozent (PD) from 2008 to 2014 and has been Titular Professor at the Institute of Nuclear Medicine, University of Zurich, since 2015. His clinical and scientific activities are mainly focused on the diagnosis and treatment of thyroid diseases as well as molecular imaging and theranostics