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Chiral Amine Synthesis
eBook
eBook
Fachbuch
2010

Chiral Amine Synthesis

Methods, Developments and Applications

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ISBN
EAN
978-3-527-62955-8
9783527629558
Artikel-Nr.
43NYD8D
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-21.7
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CHF 182.00
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142.42
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speech-bubble-svg Beschreibung
Deutsch
Ein international renommiertes Autorenteam stellt Ihnen hier aktuelle Methoden der Synthese chiraler Amine und interessante Anwendungen vor. Mit starkem Praxisbezug!

Englisch
This first comprehensive presentation of this hot and important topic compiles the most up-to-date methods for chiral amine synthesis. The international list of authors reads like a "Who's Who" of the subject, providing a large array of highly practical information concentrated into the useful and essential methods. Following an introductory chapter devoted to helping readers quickly determine which strategies to choose for their investigation, this handbook and ready reference focuses on the examination of methods that are reliable and simultaneously efficient for the synthesis of structurally diverse aliphatic and aromatic chiral amines. Modern methods and applications found in (pharmaceutical) industry are also covered.
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Stichwörter
Inhaltsverzeichnis
Preface STEREOSELECTIVE SYNTHESIS OF ALPHA-BRANCHED AMINES BY NUCLEOPHILIC ADDITION OF UNSTABILIZED CARBANIONS TO IMINES Introduction Overview of the Methods for the Preparation of Imines Chiral Auxiliary-Based Approaches Catalytic Asymmetric Nucleophilic Addition to Achiral Imines Conclusion ASYMMETRIC METHODS FOR RADICAL ADDITION TO IMINO COMPOUNDS Background and Introduction Intermolecular Radical Addition Chiral N-Acylhydrazones Asymmetric Catalysis of Radical Addition Closing Remarks ENANTIOSELECTIVE SYNTHESIS OF AMINES BY CHIRAL BRONSTED ACID CATALYSTS Introduction Carbon-Carbon Bond Forming Reactions Carbon-Hydrogen Bond Forming Reactions Carbon-Heteroatom Bond Forming Reactions Conclusion REDUCTION OF IMINES WITH TRICHLOROSILANE CATALYZED BY CHIRAL LEWIS BASES Introduction Formamides as Lewis-Basic Organocatalysts in Hydrosilylation of Imines Other Amides as Organocatalysts in Hydrosilylation of Imines Sulfinamides as Organocatalysts in Hydrosilylation of Imines Supported Organocatalysts in Hydrosilylation of Imines Mechanistic Considerations Synthetic Applications Conclusions Typical Procedures for the Catalytic Hydrosilylation of Imines CATALYTIC, ENANTIOSELECTIVE; VINYLOGOUS MANNICH REACTIONS Introduction Vinylogous Mukaiyama-Mannich Reactions of Silyl Dienolates Direct Vinylogous Mannich Reactions of Unmodified Substrates Miscellaneous Conclusion CHIRAL AMINES FROM TRANSITION-METAL-MEDIATED HYDROGENATION AND TRANSFER HYDROGENATION Scope and Related Publications Chiral Amines with a Disubstituted Nitrogen Atom, HNR*R1 Chiral Amines with Trisubstituted Nitrogen, NR*R1R2 Conclusion ASYMMETRIC REDUCTIVE AMINATION Introduction Transition Metal-Mediated Homogenous Reductive Amination Enantioselective Organocatalytic Reductive Amination Diastereoselective Reductive Amination Conclusions ENANTIOSELECTIVE HYDROGENATION OF ENAMINES WITH MONODENTATE PHOSPHORUS LIGANDS Introduction Asymmetric Hydrogenation of Enamides Asymmetric Hydrogenation of N,N-Dialkyl Enamines Conclusion and Outlook BIDENTATE LIGANDS FOR ENANTIOSELECTIVE ENAMIDE REDUCTION Introduction Catalytic Enantioselective Hydrogenation of Enamides Conclusions ENANTIOSELECTIVE REDUCTION OF NITROGEN-BASED HETEROAROMATIC COMPOUNDS Asymmetric Hydrogenation of Quinolines Asymmetric Hydrogenation of Isoquinolines Asymmetric Hydrogenation of Pyrroles Asymmetric Hydrogenation of Quinoxalines Asymmetric Hydrogenation of Pyridine Derivatives Summary and Outlook ASYMMETRIC HYDROAMINATION Introduction: Synthesis of Amines via Hydroamination Hydroamination of Simple, Nonactivated Alkenes Hydroamination of Dienes, Allenes, and Alkynes Hydroamination with Enantiomerical Pure Amines Synthesis of Chiral Amines via Tandem Hydroamination/Hydrosilylation Conclusions Experimental Section ENANTIOSELECTIVE C-H AMINATION Introduction Background Racemic C-H Amination Substrate-Controlled Chiral Amine Synthesis via C-H Amination Enantioselective C-H Amination of Achiral Substrates Conclusion CHIRAL AMINES DERIVED FROM ASYMMETRIC AZA-MORITA-BAYLIS-HILLMAN REACTION Introduction Recent Mechanistic Insights Asymmetric Aza-MBH Reaction Chiral Auxiliary-Induced Diastereoselective Aza-MBH Reaction Chiral Teriary Amine Catalysts Chiral Phosphine Catalysts Chiral Bifunctional N-Heterocyclic Carbenes Chiral Ionic Liquids as Reaction Medium Aza-MBH-Type Reaction to Obtain Chiral Amines Strategies for the Removal of Protecting Groups Selected Typical Experimental Procedures Summary and Outlook BIOCATALYTIC ROUTES TO NONRACEMIC CHIRAL AMINES Introduction Kinetic Resolution of Racemic Amines DKR and Deracemization of Amines Asymmetric Synthesis of Amines Using Transaminases Conclusions and Future Perspectives
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Biografie
Tom Nugent gained his Ph.D. in Organic Chemistry in 1995 from Virginia Tech working with Professor Tomas Hudlicky. From 1996-1997, he completed his postdoctoral studies at the University of Liverpool (Great Britain) with Professor Stanley Roberts. Over the next six years he worked as a process research chemist, first with Catalytica Fine Chemicals / DSM (Mountain View, California, 1998-2000) and then with Pharmacia/Pfizer Corporation (South San Francisco, California, 2001-2003). In 2004 he began his academic career at Jacobs University as Assistant Professor of Organic Chemistry.
Publikation
Deutschland
14.01.2010
Wiley-VCH
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Sprache
Englisch
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eBook
PDF
520 Seiten
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