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Prenatal Gene Therapy
Buch
Buch
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Fachbuch
2012

Prenatal Gene Therapy

Concepts, Methods, and Protocols

Kollektion

Methods in Molecular Biology

ISBN
EAN
978-1-61779-872-6
9781617798726
Artikel-Nr.
YPDWZEG
Bestpreis-Garantie
Kostenloser Versand
Rabatt
-22.5
%
CHF 197.00
CHF
152.68
Anzahl
1
Maximale
Lieferzeit
33
Arbeitstage
Mittwoch
15.09.2021
speech-bubble-svg Beschreibung

The emerging field of prenatal gene therapy is founded on scientific and technical advances in fetal medicine, molecular biology and gene therapy. This preclinical research subject aims at applying gene therapy during pregnancy for the prevention of human diseases caused by early onset congenital or gestation related conditions.  In Prenatal Gene Therapy: Concepts, Methods and Protocols, expert researchers in the field detail many of the protocols which are now commonly used to study gene therapy, fetal medicine and medical ethics. These include detailed protocols for vector production, for breeding and husbandry of the animal models, for  the surgical procedures of gene delivery in large and small animals and for the methods of gene transfer analysis. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 

Thorough and intuitive, Prenatal Gene Therapy: Concepts, Methods and Protocols seeks to aid scientists in the further study of prenatal disease and gene therapy projects beyond the scope of fetal medicine.

Inhaltsverzeichnis
1. The Concept of Prenatal Gene Therapy  Charles Coutelle, Simon Waddington2. Candidate Diseases for Prenatal Gene TherapyAnna L David, Simon Waddington3. Vector Systems for Prenatal Gene Therapy: Choosing Vectors for Different Applications Charles Coutelle, Simon Waddington4. Vector Systems for Prenatal Gene Therapy: Principles of Adenovirus Design and ProductionRaul Alba, Andrew H Baker and Stuart A Nicklin5. Vector Systems for Prenatal Gene Therapy: Principles of Retrovirus Vector Design and ProductionSteven J Howe and Anil Chandrashekran6. Vector Systems for Prenatal Gene Therapy: Principles of Adeno-Associated Virus Vector Design and ProductionChristopher J Binny, Amit C Nathwani 7. Vector Systems for Prenatal Gene Therapy: Principles of Non-viral Vector Design and ProductionSuet Ping Wong, Orestis Argyros and Richard P Harbottle8. Use of Manipulated Stem Cells for Prenatal TherapyJessica L. Roybal, Pablo Laje, Jesse D. Vrecenak, Alan W. Flake9. Animal Models for Prenatal Gene Therapy: Choosing the Right Model Vedanta Mehta, Donald Peebles, Anna L. David10. Animal Models for Prenatal Gene Therapy:  Rodent Models for Prenatal Gene TherapyJessica L. Roybal, Masayuki Endo, Suzanne M.K Buckley, Bronwen R. Herbert, Simon N. Waddington, Alan W. Flake11. Animal Models for Prenatal Gene Therapy: The Sheep ModelKhalil N. Abi-Nader, Michael Boyd, Alan Flake, Vedanta Mehta, Donald Peebles, Anna L. David12. Animal Models for Prenatal Gene Therapy:  The Non-human Primate Model  Citra N Mattar, Arijit Biswas, Mahesh Choolani, Jerry KY Chan13. Choice of Surrogate and Physiological Markers for Prenatal Gene TherapyJuliette Delhove, Ahad A. Rahim, Tristan R. McKay, Simon N. Waddington, Suzanne M.K. Buckley14. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy: Use of Large Animal Models with Relevance to Human ApplicationVedanta Mehta, Khalil N. Abi-Nader, David Carr, Jacqueline Wallace, Charles Coutelle, Simon Waddington, , Donald Peebles, Anna L. David15. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy: Mouse Models for Developmental Aberrations and Inadvertent Germ Line TransmissionCharles Coutellle, Simon Waddington, Michael Themis16. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy: Genotoxicity Analysis in vitro and on Small Animal Models ex vivo and in vivoMichael Themis 17. Risks, Benefits and Ethical, Legal and Societal Considerations for Translation of Prenatal Gene Therapy to Human Application Charles Coutelle , Richard Ashcroft1. The Concept of Prenatal Gene Therapy  Charles Coutelle, Simon Waddington2. Candidate Diseases for Prenatal Gene TherapyAnna L David, Simon Waddington3. Vector Systems for Prenatal Gene Therapy: Choosing Vectors for Different Applications Charles Coutelle, Simon Waddington4. Vector Systems for Prenatal Gene Therapy: Principles of Adenovirus Design and ProductionRaul Alba, Andrew H Baker and Stuart A Nicklin5. Vector Systems for Prenatal Gene Therapy: Principles of Retrovirus Vector Design and ProductionSteven J Howe and Anil Chandrashekran6. Vector Systems for Prenatal Gene Therapy: Principles of Adeno-Associated Virus Vector Design and Production 7. Vector Systems for Prenatal Gene Therapy: Principles of Non-viral Vector Design and ProductionSuet Ping Wong, Orestis Argyros and Richard P Harbottle8. Use of Manipulated Stem Cells for Prenatal TherapyJessica L. Roybal, Pablo Laje, Jesse D. Vrecenak, Alan W. Flake9. Animal Models for Prenatal Gene Therapy: Choosing the Right Model Vedanta Mehta, Donald Peebles, Anna L. David10. Animal Models for Prenatal Gene Therapy:  Rodent Models for Prenatal Gene TherapyJessica L. Roybal, Masayuki Endo, Suzanne M.K Buckley, Bronwen R. Herbert, Simon N. Waddington, Alan W. Flake11. Animal Models for Prenatal Gene Therapy: The Sheep ModelKhalil N. Abi-Nader, Michael Boyd, Alan Flake, Vedanta Mehta, Donald Peebles, Anna L. David12. Animal Models for Prenatal Gene Therapy:  The Non-human Primate Model  Citra N Mattar, Arijit Biswas, Mahesh Choolani, Jerry KY Chan13. Choice of Surrogate and Physiological Markers for Prenatal Gene TherapyJuliette Delhove, Ahad A. Rahim, Tristan R. McKay, Simon N. Waddington, Suzanne M.K. Buckley14. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy: Use of Large Animal Models with Relevance to Human ApplicationVedanta Mehta, Khalil N. Abi-Nader, David Carr, Jacqueline Wallace, Charles Coutelle, Simon Waddington, , Donald Peebles, Anna L. David15. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy: Mouse Models for Developmental Aberrations and Inadvertent Germ Line TransmissionCharles Coutellle, Simon Waddington, Michael Themis16. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy: Genotoxicity Analysis in vitro and on Small Animal Models ex vivo and in vivoMichael Themis 17. Risks, Benefits and Ethical, Legal and Societal Considerations for Translation of Prenatal Gene Therapy to Human Application Charles Coutelle , Richard Ashcroft
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31.05.2012
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Englisch
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Hardcover
392 Seiten
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