Erhältlich:
Nicht auf Lager
Buch (Softcover): Fachbuch
Aminoglycosides
Clinical Pharmacology, Precision Dosing, Safety, and Stewardship
Verlag:
Independently Published Unsere-Artikel-Nr.: P35153451
EAN: 9798188101411
Erhältlich:
Nicht auf Lager
Zustellung: Mo, 26.10.2026
Versand: Kostenlos
CHF 29.50
Beschreibung
Aminoglycosides. provides a clinically oriented and evidence-based overview of an important class of antibacterial agents widely used in the management of severe infections caused by aerobic Gram-negative bacteria and selected Gram-positive pathogens. Written in clear scientific language and organized for efficient study and consultation, this volume integrates mechanisms of action, antimicrobial spectrum, pharmacokinetics, pharmacodynamics, clinical indications, adverse reactions, drug interactions, contraindications, resistance mechanisms, therapeutic drug monitoring, and principles of antimicrobial stewardship. The book examines clinically relevant agents such as gentamicin, amikacin, tobramycin, streptomycin, neomycin, plazomicin, and other representative aminoglycosides. Particular emphasis is placed on concentration-dependent bacterial killing, the post-antibiotic effect, extended-interval dosing, renal function assessment, dose individualization, serum concentration monitoring, and the prevention of nephrotoxicity and ototoxicity. The volume also discusses the role of aminoglycosides in sepsis, complicated urinary tract infections, infective endocarditis, tuberculosis, multidrug-resistant Gram-negative infections, and combination antimicrobial therapy. Mechanisms of resistance, including aminoglycoside-modifying enzymes, target alteration, reduced permeability, efflux, and 16S rRNA methylation, are presented within their clinical context. Designed primarily for students and professionals in medicine, pharmacy, nursing, biomedical sciences, dentistry, and other health-related fields, this book can be used for academic study, clinical review, exam preparation, and professional updating. Key topics include:. - mechanisms of action and inhibition of bacterial protein synthesis;- gentamicin, amikacin, tobramycin, and streptomycin;- concentration-dependent killing and post-antibiotic effect;- conventional and extended-interval dosing strategies;- therapeutic drug monitoring and dose individualization;- nephrotoxicity, ototoxicity, and neuromuscular blockade;- renal function and pharmacokinetic adjustment;- clinical indications and combination therapy;- mechanisms of bacterial resistance;- precision dosing, safety, and antimicrobial stewardship.
Spezifikationen
Sprache
- Englisch
Autor
- Edvande Xavier dos Santos Filho
Erscheinungsjahr
- 2026
Format
- Buch (Softcover)
Anzahl Seiten
- 84