Medicinal Chemistry

"Medicinal Chemistry: Principles and Practices, 2/e" introduces the principles and practices of modern medicinal chemistry, and covers all aspects of drug discovery from the initial lead to final development. It teaches how to convert a lead compound into a potential drug and provides recent case histories as examples of successes. References to specialist monographs and reviews supplement this breadth of coverage, where the reader can find more detail on specific topics of interest if required. For this new edition, the material has been extensively revised to reflect the advances in the methods used in drug discovery over recent years. TOC:An Introduction to Drug Receptor Interactions Signal Transductionand Second Messengers Enzyme Inhibitors The Biological Evaluationof New Compounds Pharmokinetics Drug Metabolism PhysiochemicalProperties and Drug Design Quantitative Structure-Activity 1= Relationships Considerations for the Use of Computational Chemistry Techniques by Medicinal Chemists "Patent Medicine" MolcularBiology: A New Route to Drug Discovery Devising a Research Strategy Past Approaches to Discovering New Drugs as Medicines Bioisosteres, Conformational Restriction, and Pro-drugs: Approaches toLead Optimisation Case History: An Example of a ConformationalRestriction Approach The Design and Synthesis of Selective ProteinKinase C Inhibitors Discovery of 1069C - A Novel Synthetic 1= Antihumour Agent with Low Cross-Resistance Potential The Design andBiological Properties of 'Dipeptoid' Antagonists Migraine Therapy:From Serotonin to Sumatriptan Drug Development Appendices Subject Index