Erhältlich:
Nicht auf Lager
Buch (Softcover): Fachbuch
Quinolones and Fluoroquinolones
Clinical Pharmacology, Safe Use, and Antimicrobial Stewardship
Verlag:
Independently Published Unsere-Artikel-Nr.: P35301060
EAN: 9798188102852
Erhältlich:
Nicht auf Lager
Zustellung: Mo, 26.10.2026
Versand: Kostenlos
CHF 29.50
Beschreibung
Quinolones and Fluoroquinolones. provides a clinically oriented and evidence-based overview of an important class of antibacterial agents used in the treatment of a broad range of infections. Written in clear scientific language and organized for efficient study and consultation, this volume integrates mechanisms of action, antimicrobial spectrum, pharmacokinetics, pharmacodynamics, clinical indications, adverse reactions, drug interactions, contraindications, resistance mechanisms, safety monitoring, and principles of antimicrobial stewardship. The book examines clinically relevant agents such as ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, delafloxacin, and other representative quinolones and fluoroquinolones. Particular attention is given to inhibition of bacterial DNA gyrase and topoisomerase IV, concentration-dependent antibacterial activity, tissue penetration, dose adjustment, and the appropriate selection of therapy according to the site of infection and susceptibility profile. The volume also discusses the use of these drugs in urinary tract infections, respiratory tract infections, gastrointestinal infections, bone and joint infections, selected cases of tuberculosis, and infections caused by Gram-negative bacteria. Safety considerations are examined in detail, including tendinopathy, tendon rupture, peripheral neuropathy, central nervous system effects, QT-interval prolongation, dysglycemia, and clinically relevant drug interactions. Mechanisms of resistance, including target-site mutations, reduced permeability, efflux pumps, and plasmid-mediated quinolone resistance, are presented within their clinical context. The book emphasizes careful prescribing, avoidance of unnecessary exposure, and the role of antimicrobial stewardship in preserving therapeutic effectiveness. Designed primarily for students and professionals in medicine, pharmacy, nursing, biomedical sciences, dentistry, and other health-related fields, this book can be used for academic study, clinical review, exam preparation, and professional updating. Key topics include:. - mechanisms of action involving DNA gyrase and topoisomerase IV;- ciprofloxacin, levofloxacin, moxifloxacin, and related agents;- antimicrobial spectrum and clinical indications;- pharmacokinetic and pharmacodynamic principles;- urinary, respiratory, gastrointestinal, and systemic infections;- adverse reactions and major safety warnings;- drug interactions and contraindications;- mechanisms of bacterial resistance;- appropriate prescribing and antimicrobial stewardship.
Spezifikationen
Sprache
- Englisch
Autor
- Edvande Xavier dos Santos Filho
Erscheinungsjahr
- 2026
Format
- Buch (Softcover)
Anzahl Seiten
- 82