Radical Reactions in Aqueous Media

Chemists are now moving away from volatile, environmentally harmful, and biologically incompatible organic solvents. With its low cost, ready availability, and capacity to remove environmentally unfriendly by-products, water is an obvious replacement. Recent advances in free radical chemistry in water have expanded the versatility and flexibility of homolytic carbon-hydrogen, carbon-carbon, carbon -halogen bond formations in aqueous media. This textbook highlights the substantial progress which has been made in the last decade to "tame" the reactive free radical species in aqueous phase reactions. It describes carbon-hydrogen and carbon-carbon bond formations in aqueous media via radical chain and non chain reactions. , with specific emphasis on development novel methodology through understanding the mechanism and kinetics of the transformations at hand. Suitable for students of chemistry, industrial chemists and academic researchers, it combines extensive knowledge of free radical chemistry with the latest innovations and creative applications. The book describes radical reactions in organic and aqueous media and their applications in total synthesis, DNA structural probing, isotope labelling, living polymerization and various other applications. It shows that, armed with an elementary knowledge of kinetics and some common sense, it is possible to harness radicals into tremendously powerful tools for solving synthetic problems. Written with the needs of students in mind, it offers just the right level of detail for undergraduate study. All the basic principles and facts on each topic area are presented in a concise yet comprehensive style that is appropriate for both core and specialist courses. It provides a step-wise introduction, taking students from the basic principles of radical reactions through to their applications in industry and their role in biological and environmental processes. Case studies are used to illustrate reactions in landmark synthesis and problems, with outlined answers, test the reader's understanding. There are also suggestions for further reading.